A Nonproton Ligand Sensor in the Acid-Sensing Ion Channel
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چکیده
منابع مشابه
A Nonproton Ligand Sensor in the Acid-Sensing Ion Channel
Acid-sensing ion channels (ASICs) have long been considered as extracellular proton (H(+))-gated cation channels, and peripheral ASIC3 channels seem to be a natural sensor of acidic pain. Here, we report the identification of a nonproton sensor on ASIC3. We show first that 2-guanidine-4-methylquinazoline (GMQ) causes persistent ASIC3 channel activation at the normal pH. Using GMQ as a probe and...
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Acid-sensing ion channels (ASICs), which belong to the epithelial sodium channel/degenerin family, are activated by extracellular protons and are inhibited by amiloride (AMI), an important pharmacological tool for studying all known members of epithelial sodium channel/degenerin. In this study, we reported that AMI paradoxically opened homomeric ASIC3 and heteromeric ASIC3 plus ASIC1b channels ...
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ژورنال
عنوان ژورنال: Neuron
سال: 2010
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2010.09.001